KEGG   Homo sapiens (human): 1728
Entry
1728              CDS       T01001                                 
Symbol
NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1
Name
(RefSeq) NAD(P)H quinone dehydrogenase 1
  KO
K00355  NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00130  Ubiquinone and other terpenoid-quinone biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa05200  Pathways in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05225  Hepatocellular carcinoma
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06226  KEAP1-NRF2 signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
  Element
N00243  KEAP1-NRF2 signaling pathway
N00244  Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
N00245  Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
N01413  Metals to KEAP1-NRF2 signalig pathway
Drug target
Acenocoumarol: D07064
Warfarin (DG00149): D00564<US> D01280<JP> D08682
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    1728 (NQO1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1728 (NQO1)
   05208 Chemical carcinogenesis - reactive oxygen species
    1728 (NQO1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    1728 (NQO1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    1728 (NQO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.6  Acting on NADH or NADPH
   1.6.5  With a quinone or similar compound as acceptor
    1.6.5.2  NAD(P)H dehydrogenase (quinone)
     1728 (NQO1)
SSDB
Motif
Pfam: Flavodoxin_2 FMN_red
Other DBs
NCBI-GeneID: 1728
NCBI-ProteinID: NP_000894
OMIM: 125860
HGNC: 2874
Ensembl: ENSG00000181019
UniProt: P15559
Structure
Position
16:complement(69709401..69726560)
AA seq 274 aa
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
NT seq 825 nt   +upstreamnt  +downstreamnt
atggtcggcagaagagcactgatcgtactggctcactcagagaggacgtccttcaactat
gccatgaaggaggctgctgcagcggctttgaagaagaaaggatgggaggtggtggagtcg
gacctctatgccatgaacttcaatcccatcatttccagaaaggacatcacaggtaaactg
aaggaccctgcgaactttcagtatcctgccgagtctgttctggcttataaagaaggccat
ctgagcccagatattgtggctgaacaaaagaagctggaagccgcagaccttgtgatattc
cagttccccctgcagtggtttggagtccctgccattctgaaaggctggtttgagcgagtg
ttcataggagagtttgcttacacttacgctgccatgtatgacaaaggacccttccggagt
aagaaggcagtgctttccatcaccactggtggcagtggctccatgtactctctgcaaggg
atccacggggacatgaatgtcattctctggccaattcagagtggcattctgcatttctgt
ggcttccaagtcttagaacctcaactgacatatagcattgggcacactccagcagacgcc
cgaattcaaatcctggaaggatggaagaaacgcctggagaatatttgggatgagacacca
ctgtattttgctccaagcagcctctttgacctaaacttccaggcaggattcttaatgaaa
aaagaggtacaggatgaggagaaaaacaagaaatttggcctttctgtgggccatcacttg
ggcaagtccatcccaactgacaaccagatcaaagctagaaaatga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (7)   
Network (7)   
   KEGG NETWORK (7)   
Disease (1)   
   OMIM (1)   
Drug (4)   
   KEGG DRUG (4)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (9)   
   NAGAHAMA-H (6)   
   OC (1)   
Protein sequence (6)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (46)   
   RefSeq(nuc) (4)   
   GenBank (21)   
   EMBL (21)   
3D Structure (20)   
   PDB (20)   
Protein domain (2)   
   Pfam (2)   
All databases (131)   

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